Protein Details: Gap junction epsilon-1 protein

Protein ID

ICDB_Pro_1467

Protein Name

Gap junction epsilon-1 protein

Gene Name

Gje1; Cx23; Gjf1

Organism

Mus musculus (Mouse)

Length

205 amino acids

AlphaFoldDB

AF-Q9CX92-F1-model_v4.pdb

Function

Sequence

MSLNYIKNFYEGCVKPPTVIGQFHTLFFGSVRMFFLGVLGFAVYGNEALHFSCDPDKREINLFCYNQFRPITPQVFWALQLVIVLLPGAIFHLYAACKSINQDCILQKPVYTVIYVLSVLLRISLEVFAFWLQIHLFGFQVKPIYLCDTESLGKKPNILKCMVPEHFEKTIFLIAMYTFTVITMVLCVAEVFEIIFRRSCFLFKR

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Highly expressed in lens; where it is mainly found in lens fibers and to a lesser extent in lens epithelium (PubMed:18385072; PubMed:18849090). Weakly expressed in retina (PubMed:18849090). Not detected in other tissues tested (PubMed:18385072; PubMed:18849090). Not detected in other tissues tested (PubMed:18385072; PubMed:18849090). Not detected in other tissues tested (PubMed:18385072; PubMed:18849090).

DOI ID

10.1126/science.1112014; 10.1167/iovs.07-1033; 10.1016/j.ejcb.2008.08.004; 10.1016/j.exer.2016.03.025

RefSeq

NP_083998.1